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Protéines et Peptides
Fournisseur:
STEMCELL Technologies
Description:
Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine that activates NF-κB, MAPK, and PI3K/AKT pathways. Activated T cells and macrophages are the primary producers of TNF-α in response to inflammation and infectious conditions. Many other cell types have been shown to produce TNF-α, among them B cells, NK cells, mast cells, neutrophils, dendritic cells, microglia, endothelial cells, smooth muscle cells, cardiomyocytes, and fibroblasts. TNF-α has cytotoxic effects on cancer cells in vitro by stimulating anti-tumor immunosuppressive responses. TNF-α stimulates expression of E- and P-selectins, thus facilitating adhesion of neutrophils, monocytes, and memory T cells to activated platelets and endothelial cells (Zelová andamp; Hosek). Other effects of TNF-α include vasodilatation and edema formation.
Fournisseur:
STEMCELL Technologies
Description:
Interleukin 17A (IL-17A) is the founding member of the family of cytokines that includes Interleukin 17B through Interleukin 17F. It is a potent proinflammatory cytokine that plays a key role in defense against pathogens. IL-17A and IL-17F signal as homodimers or heterodimers through the same receptor, and activate NF-kB, MAPK, and C/EBP pathways (Gaffen). IL-17A receptor is expressed on a variety of cell types, including hematopoietic cell compartments. IL-17A is produced by T helper 17 cells, CD8+ T cells, γδ T cells, natural killer T cells, B cells, neutrophils, innate lymphoid cells and mesenchymal stromal cells (MSCs; Zenobia and amp; Hajishengallis; Mojsilovic <i>et al.</i>). IL-17A receptor is expressed at particularly high levels on stromal cells, including MSCs. IL-17A increases the frequency and the average size of colony-forming units-fibroblast derived from bone marrow, as well as the proliferation of bone marrow-derived MSCs. IL-17A suppresses osteogenic differentiation and bone formation of bone marrow-derived MSCs. The action of IL-17A on hematopoiesis is deeply reliant on the microenvironment and the induction of other regulators. In healthy mouse bone marrow, IL-17A stimulates myeloid and early stage erythroid progenitor cells but inhibits late stage erythroid progenitor cells (Mojsilovic <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Fibroblast growth factor 18 (FGF-18) is a growth factor and member of the FGF subfamily. FGF-18 is most similar to FGF-8 and FGF-17, and is secreted in adult lung and developing tissues (Ohbayashi <i>et al.</i>). FGF-18 signals through FGF receptor 3 (FGFR3) to regulate proliferation, differentiation, and matrix production of articular and growth plate chondrocytes <i>in vivo</i> and in vitro (Davidson <i>et al.</i>). FGF-18 has skeletal functions and protects articular cartilage by gene expression profiling and regulates proliferation and differentiation of midline cerebellar structures (Mori <i>et al.</i>). Also, recombinant human FGF-18 has been shown to effectively regulate hair growth (Song <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Interleukin 9 (IL-9) has pleiotropic functions in the immune system and signals through its specific IL-9 receptor (IL-9R) (Renauld <i>et al.</i>). IL-9/IL-9R signaling pathway mainly targets the downstream activation of JAK/STAT (janus kinase/signal transducer and activator of transcription) and subsequent phosphorylation cascades initiated by multiple kinases including IRS–PI3K–PKB (insulin receptor substrate, phosphatidyl-inositol 3-kinases, protein kinase-B) and ERK (Knoops and Renauld; Fontaine <i>et al.</i>). IL-9 has been shown to have a role in Th1/Th17-mediated inflammation and in regulatory T cell responses (Singh <i>et al.</i>; Goswami and Kaplan). IL-9/IL-9R signaling pathway represents a novel endogenous anti-apoptotic mechanism for cortical neurons (Fontaine <i>et al.</i>). IL-9 secreting T cells, termed Th9 cells, contribute to both effective immunity and immunopathological disease, and have been shown to have a role in the treatment of allergic and autoimmune disease (Kaplan <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Epidermal growth factor (EGF) is characterized by high affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter and Cohen). EGF promotes EGFR dimerization, resulting in activation of downstream pathways including PI3K, ERK1/2, JAK/STAT, β-catenin, and calcium signaling. EGF is secreted by the gut-associated salivary and Brunner’s glands, is found in a variety of body fluids, and stimulates cell proliferation and differentiation in rodent and neonatal human intestine (Wright <i>et al.</i>). Central nervous system stem cells also proliferate in response to the EGF stimulus (Reynolds and Weiss).
Fournisseur:
ACROBIOSYSTEMS
Description:
Mouse recombinant Siglec-15 (from HEK293 cells)
Numéro de catalogue:
(BIRBORB97940-100)
Fournisseur:
Biorbyt
Description:
HCV-NS4-G2
UOM:
1 * 1 EA
 Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(BIRBORB97941-100)
Fournisseur:
Biorbyt
Description:
HCV-NS4-G3
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(BIRBORB97950-100)
Fournisseur:
Biorbyt
Description:
HCV-NS5-G1
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
Biorbyt
Description:
Human recombinant SGTA (from <i>E. coli</i>)
Fournisseur:
Biorbyt
Description:
Human recombinant SUMO1 (from <i>E. coli</i>)
Fournisseur:
Biorbyt
Description:
Human recombinant CD57
Fournisseur:
Biorbyt
Description:
Human recombinant IL17 (from <i>E. coli</i>)
Fournisseur:
Biorbyt
Description:
Human Bcl2-NWGR (from <i>E. coli</i>)
Fournisseur:
Biorbyt
Description:
Human recombinant CD73 (from HEK293 cells)
Numéro de catalogue:
(BIRBORB82577-100)
Fournisseur:
Biorbyt
Description:
Recombinant west nile virus pre-M protein, N-terminal (from <i>E. coli</i>)
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
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