Synonyms:
GSK 3 Inhibitor IX, BIO, 6BIO, 6-Bromoindirubin-3'-oxime, (2Z,3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one
361550-1
361550-10MG
361550-30MG
361550-1EA
310
EUR
InStock
361550-1
361550-10MG
361550-30MG
(2'Z,3'E)-6-Bromoindirubin-3'-oxime, Millipore®
(2'Z,3'E)-6-Bromoindirubin-3'-oxime
A cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM).
Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells.