Synonyms:
ALuminon, Ammonium auritricarboxylate ATA Triammonium aurinetricarboxylate triammonium salt Ammonium aurintricarboxylate aurintricarboxylic acid ammonium salt Aluminon(C.1.No.43810) aurintricarboxylic acid triammonium salt, Ammonium 5,5'-((3-carboxylato-4-oxocyclohexa-2,5-dien-1-ylidene)methylene)bis(2-hydroxybenzoate), Aurin Tricarboxylic Acid Ammonium Salt
M-Clarity™ quality level = MQ200
A0885-25G
A0885-25GEA
71.6
EUR
InStock
A0885-25G
5,5'-(3-Carboxylato-4-oxocyclohexa-2,5-dienylidenemethylene)disalicylate de triammonium, en poudre, Sigma-Aldrich®
Aluminon
Aurintricarboxylic acid ammonium salt has been used as a nuclease inhibitor to study its effects on transfection.
Aurintricarboxylic acid readily polymerises in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis.