ALX350098M005
ENZOALX350098M005EA
171
EUR
InStock
ENZOALX350098M005
Ferutinin ≥98% (par HPLC), solide blanc à blanc cassé, Haute Pureté
Ferutinin
Estrogen receptor α activator.
Potent, naturally occuring non-steroid estrogenic compound. Agonist for estrogen receptor (ER) α and agonist/antagonist for ERβ with higher binding affinity than tamoxifen for both ERs. Electrogenic Ca²⁺ ionophore inducing mitochondrial depolarisation which can be completely blocked by cyclosporin A, suggesting that ferutinin opens the mitochondrial permeability transition pore (mPTP). In a concentration range of 1 - 50 µM ferutinin increases the permeability of thymocytes, mitochondria, sarcoplasmic reticulum, liposomes and bilayer lipid membranes for Ca²⁺.
Soluble in acetone, dichloromethane, DMSO or ethyl acetate.