Synonyms:
1-(3-Chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea
ALX550413M005
ENZOALX550413M005EA
110
EUR
InStock
ENZOALX550413M005
Fenobam ≥98% (par 1H-RMN)
Fenobam
mGluR5 antagonist.
Potent and selective non-competitive mGluR5 antagonist that displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50=87 nM).
Acts at an allosteric modulatory site shared with MPEP and binds mGluR5 with Kd values of 54 nM and 31 nM for rat and human receptors respectively. Displays anxiolytic activity following oral administration in vivo.
Soluble in DMSO or methanol.