BMLCN1200001
ENZOBMLCN1200001EA
296
EUR
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ENZOBMLCN1200001
Sp-5,6-dichloro-cBIMPS ≥98% (par HPLC)
Sp-5,6-dichloro-cBIMPS
PKA activator.
A cAMP analog which is a potent and specific activator of cAMP-dependent protein kinase. It is cell permeable and is not significantly hydrolysed by type I, II or III phosphodiesterases. It may be used to distinguish the cAMP- versus the cGMP-mediated signal transduction pathways. Surpasses the widely used but problematic dibutyryl-cAMP or 8-CPT-cAMP.
Soluble in DMSO (167 mM), dimethyl formamide (167 mM), 96 % ethanol (167 mM), methanol (25 mM), water (25 mM) and aqueous buffers such as phostphate buffered saline (pH 7.4; 1.4 mM), 25 mM TRIS (pH 7.4; 25 mM), 25 mM HEPES (pH 7.2; 35.7 mM) or Na₂HPO₄.