BMLGR1020500
ENZOBMLGR1020500EA
210.1
EUR
InStock
ENZOBMLGR1020500
13-cis-Retinoic acid ≥95% (par CCM)
13-cis-Retinoic acid
Retinoic acid receptor ligand.
Retinoic acid is the active metabolite of vitamin A. It is a potent modulator of growth and differentiation exerting its effects by binding to nuclear retinoic acid receptors (RARs) which directly regulate gene expression. All trans retinoic acid binds to RAR α, β and γ subtypes with Kd values of 0.2, 0.4 and 0.2 nM respectively. RARs function as ligand-dependent transcription factors. Retinoic Acid also promotes the differentiation of mouse embryonic stem cells into adipocytes, neurons and glia in vitro. It guides development of the posterior part of the embryo.
Soluble in DMSO (25 mg/ml) or ethanol (10 mg/ml).