BMLPE1860001
ENZOBMLPE1860001EA
252
EUR
InStock
ENZOBMLPE1860001
Ingenol-3,20-dibenzoate ≥97%
Ingenol-3,20-dibenzoate
Ingenol is a diterpenoid related to phorbol. Activates protein kinase C (PKC) and competes with [3H]phorbol dibutyrate for binding to PKCα (Ki for binding=240 nM). Induces apoptosis. Anticancer agent. Shows potent antileukemic activity in the P388 mouse assay.
Displays unusually high mouse ear inflammatory activity, even though the 20-hydroxy group is blocked with a benzoate ester. It appears likely that this high potency is due to metabolic cleavage of the 20-benzoate group, which releases the more potent ingenol 3-benzoate.
Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml).