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Anticorps
Numéro de catalogue:
(BOSSBS-12970R-A350)
Fournisseur:
Bioss
Description:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-0711R-CY5.5)
Fournisseur:
Bioss
Description:
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8167R-FITC)
Fournisseur:
Bioss
Description:
CHCHD6
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4062R-CY5)
Fournisseur:
Bioss
Description:
Glycerol kinase catalyzes the formation of glycerol 3 phosphate from ATP and glycerol. Dihydroxyacetone and L glyceraldehyde can also act as acceptors; UTP and, in the case of the yeast enzyme, ITP and GTP can act as donors. It provides a way for glycerol derived from fats or glycerides to enter the glycolytic pathway.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8168R-A555)
Fournisseur:
Bioss
Description:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8168R-A680)
Fournisseur:
Bioss
Description:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8168R-CY7)
Fournisseur:
Bioss
Description:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4061R-A680)
Fournisseur:
Bioss
Description:
The protein encoded by this gene localises to the inner mitochondrial membrane and catalyses the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidises NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8168R-A750)
Fournisseur:
Bioss
Description:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2891R-A350)
Fournisseur:
Bioss
Description:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6842R-CY5.5)
Fournisseur:
Bioss
Description:
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6842R-CY7)
Fournisseur:
Bioss
Description:
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4268R-A750)
Fournisseur:
Bioss
Description:
Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8320R-CY5.5)
Fournisseur:
Bioss
Description:
HEATR3 is a 680 amino acid protein existing as three alternatively spliced isoforms and containing two HEAT (Huntingtin, elongation factor 3 (EF3), protein phosphatase 2A (PP2A) and the yeast PI3-kinase Tor1) repeats. HEAT repeats form rod-like helical structures that are involved in intracellular transport. HEATR3 is encoded by a gene located on human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, a gastrointestinal inflammatory condition.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4268R-HRP)
Fournisseur:
Bioss
Description:
Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8320R-A350)
Fournisseur:
Bioss
Description:
HEATR3 is a 680 amino acid protein existing as three alternatively spliced isoforms and containing two HEAT (Huntingtin, elongation factor 3 (EF3), protein phosphatase 2A (PP2A) and the yeast PI3-kinase Tor1) repeats. HEAT repeats form rod-like helical structures that are involved in intracellular transport. HEATR3 is encoded by a gene located on human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, a gastrointestinal inflammatory condition.
UOM:
1 * 100 µl
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