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Anticorps
Numéro de catalogue:
(BOSSBS-8650R-CY5)
Fournisseur:
Bioss
Description:
The sense of taste is essential for the survival of organisms. For example, the ability to identify sweet-tasting foods enables animals to seek out food with high nutritive value, whereas the ability to identify bitter substances enables them to avoid the ingestion of potentially harmful substances. A family of integral membrane proteins are involved in taste perception and include T1R, which is involved in sweet taste perception and T2R, which is involved in bitter taste perception. Both types of taste receptors couple to various G proteins to initiate signal transduction cascades. Specifically, T2R38 is expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Variations in T2R38 are associated with the ability to taste the bitter chemical phenylthiocarbamide (PTC), also called thiourea tasting.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8650R-A647)
Fournisseur:
Bioss
Description:
The sense of taste is essential for the survival of organisms. For example, the ability to identify sweet-tasting foods enables animals to seek out food with high nutritive value, whereas the ability to identify bitter substances enables them to avoid the ingestion of potentially harmful substances. A family of integral membrane proteins are involved in taste perception and include T1R, which is involved in sweet taste perception and T2R, which is involved in bitter taste perception. Both types of taste receptors couple to various G proteins to initiate signal transduction cascades. Specifically, T2R38 is expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Variations in T2R38 are associated with the ability to taste the bitter chemical phenylthiocarbamide (PTC), also called thiourea tasting.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8650R-FITC)
Fournisseur:
Bioss
Description:
The sense of taste is essential for the survival of organisms. For example, the ability to identify sweet-tasting foods enables animals to seek out food with high nutritive value, whereas the ability to identify bitter substances enables them to avoid the ingestion of potentially harmful substances. A family of integral membrane proteins are involved in taste perception and include T1R, which is involved in sweet taste perception and T2R, which is involved in bitter taste perception. Both types of taste receptors couple to various G proteins to initiate signal transduction cascades. Specifically, T2R38 is expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Variations in T2R38 are associated with the ability to taste the bitter chemical phenylthiocarbamide (PTC), also called thiourea tasting.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5444R-A750)
Fournisseur:
Bioss
Description:
The ILK protein is important in different biological pathways such as cell adhesion, anchorage-dependent cell cycle progression, oncogenic transformation, and growth factor signaling. The kinase activity of ILK is low in non-activated cells; its activity is stimulated by cell-ECM interactions and by certain growth factors. 3 Negative regulation of ILK is mediated by two phosphatases: PTEN, a tumor suppressor lipid sphatase, and ILKAP, a PP2C protein phosphatase. In tumor cells that do not express PTEN protein, ILK is constitutively active.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1329R-A488)
Fournisseur:
Bioss
Description:
The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12310R-CY5)
Fournisseur:
Bioss
Description:
LRRC19
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6119R-CY5)
Fournisseur:
Bioss
Description:
May be involved in the regulation of cellular proliferation and/or differentiation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8874R-A680)
Fournisseur:
Bioss
Description:
The G protein-coupled receptor TGR5 is a 330-amino acid protein that is almost universally expressed in human tissues including heart, skeletal muscle, spleen, kidney, liver, small intestine, placenta, and leukocytes, but not in brain, colon (without mucosa), thymus, or lung. TGR5 is sensitive to bile acids and responds through a significant mechanism that coordinates energy homeostasis. Bile acids activate mitogen-activated protein (MAP) kinase pathways, specifically induce TGR5 internalisation, promote an increase of guanosine 5'-O-3-thio-triphosphate binding in membrane fractions, and cause rapid intracellular cAMP production. Bile acids also provoke TGR5 to suppress macrophage functions. TGR5-controlled signaling pathways may be good candidates for drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5253R-A680)
Fournisseur:
Bioss
Description:
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabiliser of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12316R-CY7)
Fournisseur:
Bioss
Description:
Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12173R-CY7)
Fournisseur:
Bioss
Description:
KCNF1 is a multi-pass membrane-bound protein that acts as an ion channel and is generally expressed as a heterotetramer of potassium channeling proteins. Formerly known as kH1, KCNF1 is usually found as a heteromer with three other potassium channel proteins, KCNG3, KV6.3 and KCNV2. As a potassium channel protein, KCNF1 plays a role in regulating apoptosis and proliferation of pulmonary artery smooth muscle (PASM) cells. Bone morphogenetic proteins (BMPs) restrict proliferation and can induce apoptosis in normal human PASM cells and will upregulate expression of KCNF1 in PASM cells in vitro. KCNF1 is expressed in heart, brain, liver, skeletal muscle, kidney and pancreas.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5114R-CY3)
Fournisseur:
Bioss
Description:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008]
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-0621R-A750)
Fournisseur:
Bioss
Description:
Centromeric histone H3-like protein-2.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5830R-A555)
Fournisseur:
Bioss
Description:
Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2433R-A350)
Fournisseur:
Bioss
Description:
Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5831R-A350)
Fournisseur:
Bioss
Description:
May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.
UOM:
1 * 100 µl
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