Anticorps
Fournisseur:
Biotium
Description:
This MAb reacts with a 28 kDa chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4 T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.
Fournisseur:
Biotium
Description:
This MAb reacts with a reduction-resistant epitope present in both free and SIgA bound Secretory Component. It does not react with the cell lines lacking secretory component. The antibody is useful for studying the distribution and level of both free and bound secretory component. Secretory component is differentially expressed in epithelium, and the antibody is a popular marker for identifying subpopulations of epithelial cells and epithelial differentiation. The Secretory component antibody is a useful research tool for studying mucosal immunity, inflammation, remodeling, differentiation and tumorigenesis, all processes associated with differential secretory component expression.
Fournisseur:
Biotium
Description:
Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.
Fournisseur:
Biotium
Description:
Recognizes a protein of 185 kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. C-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.
Fournisseur:
Biotium
Description:
Recognizes a protein of 185 kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. C-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.
Fournisseur:
Biotium
Description:
Recognizes a protein of 185 kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. C-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.
Fournisseur:
Biotium
Description:
Recognizes a protein of 185 kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. C-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.
Numéro de catalogue:
(USBIS4283-50-APC)
Fournisseur:
US Biological
Description:
Anti-STK33 Rabbit Polyclonal Antibody (APC (Allophycocyanin))
UOM:
1 * 200 µl
Numéro de catalogue:
(USBIS4283-30A-FITC)
Fournisseur:
US Biological
Description:
Anti-STK19 Rabbit Polyclonal Antibody (FITC (Fluorescein))
UOM:
1 * 200 µl
Numéro de catalogue:
(USBIS4283-34-HRP)
Fournisseur:
US Biological
Description:
Anti-SRPK3 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
UOM:
1 * 200 µl
Numéro de catalogue:
(USBIS4283-30-FITC)
Fournisseur:
US Biological
Description:
Anti-STK19 Rabbit Polyclonal Antibody (FITC (Fluorescein))
UOM:
1 * 200 µl
Numéro de catalogue:
(USBIS4283-34-PE)
Fournisseur:
US Biological
Description:
Anti-SRPK3 Rabbit Polyclonal Antibody (PE (Phycoerythrin))
UOM:
1 * 200 µl
Numéro de catalogue:
(BOSSBS-3866R-A647)
Fournisseur:
Bioss
Description:
Protor-1 plays an important role in regulation of PDGF receptor expression and in modulation of PDGF signaling. It is thought that Protor-1 may act as a tumor suppressor in breast cancer.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3866R-A488)
Fournisseur:
Bioss
Description:
Protor-1 plays an important role in regulation of PDGF receptor expression and in modulation of PDGF signaling. It is thought that Protor-1 may act as a tumor suppressor in breast cancer.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3864R-CY5.5)
Fournisseur:
Bioss
Description:
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
UOM:
1 * 100 µl
Numéro de catalogue:
(USBI043702-APC)
Fournisseur:
US Biological
Description:
Anti-VAMP4 Rabbit Polyclonal Antibody (APC (Allophycocyanin))
UOM:
1 * 200 µl
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