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Anticorps
Numéro de catalogue:
(BOSSBS-2955R-A350)
Fournisseur:
Bioss
Description:
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6769R-CY7)
Fournisseur:
Bioss
Description:
Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2897R-FITC)
Fournisseur:
Bioss
Description:
ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. Isoform 2 lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized. Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2); also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1030R-A647)
Fournisseur:
Bioss
Description:
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-10309R-FITC)
Fournisseur:
Bioss
Description:
Cenexin1 is an isoform of ODF2, that unlike ODF2 is present in several somatic cell types. Cenexin1 acts as a general scaffold protein that is specifically localised to the distal/subdistal appendages of mother centrioles. Cenexin1 is required for proper localization of Plk1 to the centrosomes. This centrosomal localization of Plk1 is required for proper microtubule function. Cenexin1 recruits Plk1 via a C-terminal extension of cenexin1 that is not present in ODF2. Cenexin1 is required for proper mitotic progression; depletion of Cenexin1 ultimately leads to chromosome missegregation and apoptosis. The ODF2 (outer dense fiber 2) gene encodes both ODF2 and Cenexin1, which have very different functions. ODF2 is a major component of sperm tail outer dense fibers (ODFs). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. They may help to maintain the passive elastic structures and elastic recoil of the sperm tail, and may also modulate sperm motility.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6271R-A750)
Fournisseur:
Bioss
Description:
Probable receptor with tyrosine-protein kinase activity; important for development.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6272R-A488)
Fournisseur:
Bioss
Description:
The protein encoded by this gene belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The similar protein in yeast has both D-lactate and D-glycerate dehydrogenase activities. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3396R-A647)
Fournisseur:
Bioss
Description:
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1126R-A647)
Fournisseur:
Bioss
Description:
Serotonin (pronounced) (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesized in serotonergic neurons in the central nervous system (CNS) and enterochromaffin cells in the gastrointestinal tract of animals including humans. Serotonin is also found in many mushrooms and plants, including fruits and vegetables.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3395R-A680)
Fournisseur:
Bioss
Description:
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15379R-HRP)
Fournisseur:
Bioss
Description:
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) protein family, with an N-terminal PDZ domain, a central src homology 3 region (SH3), and a C-terminal guanylate kinase-like (GUK) domain. The protein is localised to the outer limiting membrane in the retina, and is thought to function in photoreceptor polarity and the organisation of specialised intercellular junctions. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13461R-A555)
Fournisseur:
Bioss
Description:
GMPPB is a 360 amino acid protein that belongs to the transferase hexapeptide repeat family and is involved in protein modification pathways. Functioning as a GDP-mannose pyrophosphorylase, GMPPB enzymatically catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose and a free phosphate, a reaction that is involved in the production of N-linked oligosaccharides. Defects in the gene encoding GMPPB that cause errors in the glycosylation pathway may lead to congenital disorders of glycosylation (CDG). CDGs are multisystemic diseases that often involve both the central and peripheral nervous systems and are often characterized by endocrine and coagulation disorders. GMPPB is expressed as two isoforms due to alternative splicing events.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2242R-CY5.5)
Fournisseur:
Bioss
Description:
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5238R-CY5)
Fournisseur:
Bioss
Description:
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9091R-FITC)
Fournisseur:
Bioss
Description:
Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleous.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7672R-CY7)
Fournisseur:
Bioss
Description:
A single transmembrane protein highly expressed in embryonic tissues and involved in inducing apoptosis.
UOM:
1 * 100 µl
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