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Protéines et Peptides
Fournisseur:
Biorbyt
Description:
Human recombinant CTGF HEK (from HEK293 cells)
Fournisseur:
Biorbyt
Description:
Rubella capsid
Fournisseur:
Biorbyt
Description:
Human recombinant D4GDI (from <i>E. coli</i>)
Fournisseur:
Biorbyt
Description:
Human CD4 (from E. coli)
Fournisseur:
Biorbyt
Description:
Dengue envelope-2 22 kDa
Fournisseur:
Biorbyt
Description:
Dengue envelope-3 22 kDa
Fournisseur:
Biorbyt
Description:
Rhesus macaque G-CSF (from <i>E. coli</i>)
Fournisseur:
Biorbyt
Description:
Human UBC5 (from <i>E. coli</i>)
Fournisseur:
Biorbyt
Description:
Human recombinant LGALS1 (from <i>E. coli</i>)
Numéro de catalogue:
(STMC78083.1)
Fournisseur:
STEMCELL Technologies
Description:
Interleukin 6 receptor (IL-6R) alpha is a type I transmembrane glycoprotein that forms a complex with type I transmembrane signal transducer protein gp130 (CD130) and mediates the biological activities of IL-6. IL-6 binds to the membrane-bound non-signaling IL-6R alpha (mIL-6R), and the complex binds to two molecules of gp130 and leads to ‘classical’ IL-6-signal transduction, which includes activation of JAK/STAT, ERK, and PI3K signal transduction pathways (Scheller <i>et al.</i>). In contrast, a soluble form of IL-6R alpha (sIL-6R), which comprises the extracellular portion of the receptor, binds to the secreted IL-6 to form a complex that promotes bioavailability of IL-6. The complex of IL-6 and sIL-6R can bind to gp130 on cells that do not express the IL-6R and are unresponsive to IL-6. This process is known as trans-signaling (Hunter and Jones; Rose-John S). sIL-6R regulates both local and systemic IL-6-mediated events. Elevated levels of sIL-6R have been documented in several disease conditions such as rheumatoid arthritis, myeloma, and Crohn’s disease (Jones <i>et al.</i>; Mihara <i>et al.</i>).
UOM:
1 * 50 µG
 Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
Fibroblast growth factor 4 (FGF-4) is a member of the FGF superfamily (Beenken and Mohammadi). FGF-4 is expressed in pluripotent stem cells and is implicated in various stages of development and morphogenesis in a variety of organisms (Kosaka <i>et al.</i> 2009). FGF-4 has been shown to have an ability to promote neural stem cell proliferation and neuronal differentiation in the postnatal brain (Kosaka <i>et al.</i> 2006). FGF-4 has also been shown to increase the proliferation rate of mesenchymal stem cells (Farré <i>et al.</i>). FGF-4 supports the maintenance and self-renewal properties of human embryonic stem cells and also promotes the proliferation of these cells (Mayshar <i>et al.</i>). In the mouse, the Fgf4 gene also supports proliferation of the inner cell mass (ICM) and postimplantation embryos (Feldman <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Vascular endothelial growth factor (VEGF-165) is a heparin-binding homodimeric glycoprotein involved in embryonic vasculogenesis and angiogenesis. VEGF binds to VEGFR-1 (R1) and VEGFR-2 (R2), and activates Raf/MEK/ERK and PI3K/AKT pathways (Ferrara <i>et al.</i>). It plays an important role in neurogenesis both in vitro and in vivo (Storkebaum <i>et al.</i>). It has neurotrophic effects on neurons of the central nervous system and promotes growth and survival of dopaminergic neurons and astrocytes. VEGF also promotes growth and survival of vascular endothelial cells, monocyte chemotaxis, and colony formation by granulocyte-macrophage progenitor cells (Ferrara <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Monocyte chemotactic protein-1 (MCP-1), also known as CCL2, is a member of the CC family of chemokines. The protein is primarily induced by platelet-derived growth factor (PDGF) gene (Cochran <i>et al.</i>). The biological effects of MCP-1 are mediated via the specific G-protein-coupled receptor CCR2 which in turn activates signal transduction pathways leading to monocyte transmigration (Sozzani <i>et al.</i>). Migration of monocytes from the bloodstream across the vascular endothelium is required for routine immunological surveillance of tissues, as well as other immunomodulatory effects. MCP-1 is produced by a variety of cell types, including fibroblasts and endothelial, epithelial, smooth muscle, mesangial, astrocytic, monocytic, and microglial cells, which are important for antiviral responses in the peripheral circulations and in tissues (Cushing <i>et al.</i>; Deshmane <i>et al.</i>). MCP-1 plays a role in physiological processes such as neurogenesis, neuroprotection, and neurotransmission and has important implications in neurological disorders such as multiple sclerosis and Alzheimer’s disease, in which it is produced during neuroinflammation at the sites of lesions (Conductier <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Sonic hedgehog (Shh) is a member of the Hedgehog family of secreted signaling proteins that has a prominent role in patterning during early mammalian development (Ho and Scott). It is expressed during early embryogenesis in a variety of tissues (Finco <i>et al.</i>). During patterning of the central nervous system, Shh directly acts on cells to specify neural cell fates, regulates proliferation and survival of oligodendrocyte precursors and neural crest cells and stimulates proliferation, differentiation, and axon growth (Ho and Scott; Martí). Shh also regulates T cell differentiation and activation (Crompton <i>et al.</i>). Recombinant Mouse Shh is a fully biologically active molecule.
Numéro de catalogue:
(BIRBORB180419-50)
Fournisseur:
Biorbyt
Description:
Human recombinant TIM3 (from cells)
UOM:
1 * 50 µG
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(BIRBORB83026-100)
Fournisseur:
Biorbyt
Description:
Human recombinant IFN beta
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
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