0210007105
02100071.1
02100071.5
0210007101
ICNA0210007105EA
1015
EUR
InStock
ICNA0210007105
ICNA02100071.1
ICNA02100071.5
ICNA0210007101
Cytosine-β-D-arabinofuranoside hydrochloride, en poudre
Cytosine-beta-D-arabinofuranoside hydrochloride
Soluble in water (50 mg/ml - clear, colourless solution).
Cytosine β-D-arabinofuranoside hydrochloride is an anti-leukemic agent. It results in DNA fragmentation and inhibition of replication. In addition this compound does not have any effects on RNA synthesis. Cytosine β-D-arabinofuranoside hydrochloride can function as a ligand which shows strong affinity and selectivity for the Translocator protein (TSPO). Studies suggest that cytosine β-D-arabinofuranoside hydrochloride can down-regulate deoxycytidine kinase in acute myeloid leukemia murine cell lines which inhibits the phosphorylation of several deoxyribonucleosides. Furthermore, cytosine β-D-arabinofuranoside hydrochloride can be inhibited in myeloid leukemic cells via suppression of ENT1 promoter activity, responsible for transporting cytosine β-D-arabinofuranoside into the cell.
Cytosine β-D-arabinofuranoside hydrochloride is a selective inhibitor of DNA synthesis that does not affect RNA synthesis in mammalian cells. It is used as an antineoplastic and antiviral agent.
Ara-C an anti-leukemia agent is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. It does not inhibit RNA synthesis.