0216005090
0216005094
0216005050
0216005080
0216005083
0216005091
ICNA0216005090EA
135
EUR
InStock
ICNA0216005090
ICNA0216005094
ICNA0216005050
ICNA0216005080
ICNA0216005083
ICNA0216005091
NADH-Na2,forme réduite ≥98%
NADH-Na2 forme réduite
White Powder, soluble in water or aqueous buffers (50 mg/ml); soluble in 0,01 N Sodium hydroxide (100 mg/ml - clear to slightly hazy, yellowish solution).
A high purity preparation of NADH suitable for most applications.
Meets or exceeds NRC specifications
β-NADH a pyridine nucleotide and biologically active form of nicotinic acid, is a coenzyme necessary for the catalytic reaction of certain enzymes.
β-Nicotinamide adenine dinucleotide and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalysed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases). As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.
NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, beta-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD+/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease.
Attention: pH 7,5 - 9,5 (10% aq soln)
Store at −0 °C. Store desiccated. Protect from light. Store under nitrogen.