Synonyms:
4-[(4S)-4-AMino-4-carboxybutyl]-1-[(5S)-5-aMino-5-carboxypentyl]-3,5-bis[(3S)-3-aMino-3-carboxypropyl]pyridiniuM, 2-amino-6-[4-(4-amino-4-carboxy-butyl)-3,5-bis(3-amino-3-carboxy-propyl)pyridin-1-yl]hexanoic acid, ELA Desmosine
0219137805
0219137801
ICNA0219137805EA
597
EUR
InStock
ICNA0219137805
ICNA0219137801
Desmosine 99%, solide jaune
Desmosine
Desmosine is prepared according to the method of Starcher et al. from hydrolysed neck ligament by solvent extraction and chromatography on Dowex 50.
NOTE: Extremely hygroscopic and must be stored over a desiccant such as silica gel.
Desmosine is a tetrafunctional, pyridinium ring-containing amino acids involved in elastin cross-linking. A desmosine cross-link is formed from three allysyl side chains plus one unaltered lysyl side chain from the same or neighbouring polypeptides.
Desmosine is responsible for the cross-linking of elastin leading to the formation of insoluble fibers. Urinary excretion of desmosine is a useful indicator of elastin breakdown resulting from increased elastase activity. It also acts as a biomarker of elastin degradation in chronic obstructive.
Attention: Research Use Only (RUO). Extremely hygroscopic and must be stored over a desiccant such as silica gel.