Synonyms:
IBMX
ICNA0219526205EA
979.8
EUR
InStock
ICNA0219526205
ICNA02195262.2
ICNA0219526201
ICNA02195262.1
3,7-Dihydro-3-isobutyl-1-méthyl-1H-purine-2,6-dione, poudre blanche
3,7-Dihydro-3-isobutyl-1-méthyl-1H-purine-2,6-dione
IBMX has been shown to be a potent, non-specific inhibitor of adenosine 3',5'-cyclic monophosphate phosphodiesterase (cAMP PDE)4, significantly more effective than theophylline. Also inhibits cGMP phosphodiesterases. IBMX inhibits cyclic nucleotide PDE with subsequent inhibition of cyclic nucleotide hydrolysis, resulting in accumulation of cyclic AMP and guanosine 3',5'-cyclic monophosphate.
IBMX helps in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1,3 μM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells both in vivo and in vitro in mice.
Soluble in Krebs-Henseleit bicarbonate buffer, ethanol (10 mg/ml or 25 mg/ml with sonication), DMSO (1 M with warming), or aqueous NaOH (pH 9,5); slightly soluble in water (0,3 mg/ml hot water). Solubility in 45% (w/v) aqueous 2-hydroxy-propyl-b-cyclodextrin is 3,2 mg/ml.
Attention: Research Use Only (RUO).