Synonyms:
1,2,3,6-Tetrahydro-2,3'-bipyridine, (R,S)-Anatabine
11001-5
11001-10
11001-50
11001-100
CAYM11001-5EA
64.5
EUR
InStock
CAYM11001-5
CAYM11001-10
CAYM11001-50
CAYM11001-100
D,L-Anatabine ≥95%
D,L-Anatabine
(R,S)-Anatabine is a minor alkaloid produced in plants of the Solanaceae family, including tobacco.
The detection of (R,S)-anatabine in urine is used as an indicator of tobacco use, particularly when nicotine-containing products (gum, patches, inhalers, and medications) are also being used. (R,S)-Anatabine increases nicotine self-administration and locomotor activity in rats. Of note, (R,S)-anatabine diminishes amyloid beta (Aβ) production in vitro and in vivo. (R,S)-Anatabine reduces (600 µg/ml) the transcription and protein levels of β-secretase, lowering the amount of Aβ1-40 and Aβ1-42 in a dose dependent manner in SHSY-5Y cells. (R,S)-Anatabine also dose dependently inhibits NF-κB activation.