14998-10
14998-25
14998-100
14998-50
CAYM14998-10EA
83.9
EUR
InStock
CAYM14998-10
CAYM14998-25
CAYM14998-100
CAYM14998-50
Paroxetine hydrochloride ≥98%
Paroxetine hydrochloride
Paroxetine is a phenylpiperidine derivative that potently and selectively inhibits the reuptake of serotonin, blocking the human serotonin transporter with a Ki value of 0,72 nM.
It less effectively blocks the human norepinephrine and dopamine transporters (Ki = 440 and 1,900 nM, respectively). Paroxetine also inhibits, at concentrations in excess of 1 µM, nitric oxide synthase activity in the cytosol of hamster brain. Selective serotonin uptake inhibitors, including paroxetine, are used in cases of depression and anxiety disorder.