0210555110
0210555125
0210555180
ICNA0210555110EA
35.4
EUR
InStock
ICNA0210555110
ICNA0210555125
ICNA0210555180
5-Fluoro-2'-deoxyuridine (Floxuridine) ≥98%, poudre blanche
5-Fluoro-2'-deoxyuridine (Floxuridine)
5-Fluorodeoxyuridine is an antineoplastic agent, which acts as an anti-metabolite. When administrated by rapid injection it acts as flurouracil, but when infused slowly, usually intra-arterially, it is converted to active F-dUMP, which leads to enhanced inhibition of DNA synthesis. It inhibits DNA synthesis by blocking thymidylic acid synthetase.
- Extinction Coefficient (E1%): EmM = 8.91 (0.1 M phosphate buffer, pH 6.0) (Lit.)
- Optical Rotation: +37 ° (10 mg/mL in water at 25 °C) (Lit.)
- pKa:7.6 (Lit.)
5-Fluorodeoxyuridine can be used to target thymidylate synthetase in cancer chemotherapy. Experimental anticancer agent shown to have activity against a variety of malignant neoplasms, including mouse mammary tumors and colorectal carcinomas.
Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase. Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.
Soluble in water (clear, colourless solution); DMF.
Attention: Research Use Only (RUO).