Synonyms:
5-Aza-2′-deoxycytidine, Decitabine, 5-Aza-1-(2-deoxy-beta-D-ribofuranosyl)cytosine, 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one, 2′-Deoxy-5-azacytidine 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one Decitabine, 4-Amino-1-(2-deoxy-beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
0215480305
0215480310
0215480325
0215480350
ICNA0215480305EA
128
EUR
InStock
ICNA0215480305
ICNA0215480310
ICNA0215480325
ICNA0215480350
5-Aza-2'-deoxycytidine, poudre cristalline blanche
5-Aza-2'-deoxycytidine
5-Aza-2'-deoxycytidine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.
5-Aza-2′-Deoxycytidine has been founf to induce changes in the differentiated state of cultured mouse embryo cells and additionally inhibits DNA methyltransferase (Dnmt). DNA methylation has been noted to be important in determining apoptotic susceptibility to histone deacetylase inhibitors, and its prevention can cause gene silencing and transcriptional repression. Other studies suggest that cell exposure to 5-Aza-2′-Deoxycytidine causes a change in replication timing, reactivation of repressed genes, and decondensation of heterochromatin. Furthermore, this agent demonstrates the ability to induce histone hyperacetylation in murine centromeric heterochromatin and also affect intranuclear distribution of histone deacetylase 2.
5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.
Slightly soluble in acidic aqueous solution such as 1N HCl and in acetic acid: water (1:1): soluble - 50 mg/ml.