0219150425
0219150480
0219150490
0219150491
ICNA0219150425EA
53
EUR
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ICNA0219150425
ICNA0219150480
ICNA0219150490
ICNA0219150491
Folinic acid calcium salt pentahydrate, poudre jaune pâle
Folinic acid calcium salt pentahydrate
Folinic acid calcium salt, pentahydrate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate.
In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.
Intermediate product of the metabolism of folic acid; the active form into which that acid is converted in the body, ascorbic acid being a necessary factor in the conversion process.
Freely soluble in water (100 mg/mL-clear to slightly hazy solution); almost insoluble in ethanol, alcohol.