0215673880
0215673883
0215673891
ICNA0215673880EA
45
EUR
InStock
ICNA0215673880
ICNA0215673883
ICNA0215673891
Tamoxifen, poudre blanche
Tamoxifen
Protein kinase C inhibitor (IC50 = 50-200 µM depending on assay conditions in MCF-7 cells or IC50 = 100 µM in rat brain). The PKC inhibition is also dependent on the phosopholipid concentration. Also inhibits both calmodulin-dependent and calmodulin-independent Ca2+-, Mg2+-ATPase. Tamoxifen is a selective estrogen response modifier (SERM), anti-angiogenetic factor. It is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Tamoxifen has been used to facilitate the recombination of ect2flox allele in mouse organs. It has also been used to study its effect on lipopolysaccharide (LPS)-induced microglial activation
Tamoxifen is a Protein kinase C inhibitor. It induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
- Presentation: White Powder
- pKa: approximately 8.85; approximately 6.9 (in Triton® X-100)
- Practically insoluble in water (< 0.01% at 20 °C); soluble in methanol, ethanol, 2-propanol, propylene glycol, chloroform (50 mg/mL - clear, colorless to faint yellow solution) or DMSO.
- Storage temperature: Store at +4 °C.
Storage temperature.: +4 °C