Synonyms:
D-2-Amino-5-phosphonovaleric acid, (R)-2-Amino-5-phosphonopentanoic acid, D-AP5
14539-10
14539-50
14539-100
14539-5
CAYM14539-10EA
172
EUR
InStock
CAYM14539-10
CAYM14539-50
CAYM14539-100
CAYM14539-5
(R)-(-)-2-Amino-5-phosphonopentanoic acid ≥95%
(R)-(-)-2-Amino-5-phosphonopentanoic acid
D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (Kd=1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors.
D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity. AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.