15543-1
15543-10
15543-25
15543-5
CAYM15543-1EA
55.5
EUR
InStock
CAYM15543-1
CAYM15543-10
CAYM15543-25
CAYM15543-5
Hydroxy-2-naphthalenylmethylphosphonic acid ≥95%, solide cristallin
Hydroxy-2-naphthalenylmethylphosphonic acid
HNMPA is a cell impermeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity.
It does not affect protein kinase C or cyclic AMP-dependent protein kinase activities. HNMPA inhibits the insulin-stimulated autophosphorylation of the 95 kDa β-subunit of the insulin receptor with an IC50 value of 200 µM in-vitro.