14612-5
14612-10
14612-25
14612-50
CAYM14612-5EA
65.8
EUR
InStock
CAYM14612-5
CAYM14612-10
CAYM14612-25
CAYM14612-50
7-Dehydrocholesterol ≥90%, solide cristallin
7-Dehydrocholesterol
7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol.
It is reduced to cholesterol by the enzyme 3β-hydroxysterol-Δ7-reductase (DHCR7) in the last step of cholesterol biosynthesis. 7-DHC accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7 gene and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features.1,2 It is highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS.1 7-DHC levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944 (Item No. 14611).1 7-DHC is a provitamin that is converted to vitamin D3 (Item No. 11792) by ultraviolet-B (UVB) light in a human skin equivalent system and in isolated human skin samples.