Synonyms:
Nα-p-Tosyl-DL-lysine chloromethyl ketone hydrochloride, TLCK
616382-250
616382-50
616382-250EA
329
EUR
InStock
616382-250
616382-50
Nα-(p-Toluenesulphonyl)-DL-lysine chloromethyl ketone hydrochloride ≥95% (par analyse élémentaire), solide blanc cassé, Calbiochem®
Nalpha-(p-Toluenesulphonyl)-DL-lysine chloromethyl ketone hydrochloride
Inhibits trypsin-like serine proteinases.
Irreversibly inactivates trypsin without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to the target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC₅₀=80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemia cells and normal thymocytes.