14882-100
14882-25
14882-50
14882-500
CAYM14882-100EA
139
EUR
InStock
CAYM14882-100
CAYM14882-25
CAYM14882-50
CAYM14882-500
Dichlorure de 2,2'-dithiodi(éthylammonium) ≥95%, solide cristallin
Dichlorure de 2,2'-dithiodi(éthylammonium)
Cystamine is an organic disulfide that inhibits TGM2 with an IC50 value of approximately 2.5 mM.
It is orally available and is neuroprotective in mouse models of Huntington’s disease. Cystamine also inhibits caspase 3, increases intracellular glutathione, and reduces inflammation in a rat model of inflammatory bowel disease.
Tissue transglutaminase (TGM2) post-translationally modifies proteins by catalyzing intermolecular cross-linkages between glutamine and lysine side chains. TGM2 has roles in neurodegenerative disorders, celiac sprue, cancer, and fibrotic diseases.