Synonyms:
2-(2-Amino-3-methoxyphenyl)-4H-chromen-4-one
, 2-(2-Amino-3-methoxyphenyl)chromone
, PD 98059
, 2'-Amino-3'-methoxyflavone
, 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
ENZOBMLEI3600005EA
110
EUR
InStock
ENZOBMLEI3600005
PD 98059 ≥95% (par HPLC)
PD 98059
PD-98059 is a potent and selective inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK thereby inhibiting the phosphorylation and the activation of MAP kinase. PD-98059 is cell permeable. In PC12 pheochromocytoma cells, it completely blocked the increase in MAP kinase activity produced by NGF, IC50=2µM. Enhances self-renewal of embryonic stem cells PD-98059 is an invaluable tool to help elucidate the role of the MAPK cascade in a variety of biological systems. Inhibits cell growth and proliferation in acute myelogenous leukemia cell lines by causing cell arrest.
Pale yellow solid
Soluble in DMSO (6.5mg/ml); 25mg/ml in anhydrous DMSO), methanol, dichlormethane and 100% ethanol (0.6mg/ml).