Synonyms:
N-Allyl-6-bromoquinazolin-4-amine
BMLEI3970005
BMLEI3970025
ENZOBMLEI3970005EA
110
EUR
InStock
ENZOBMLEI3970005
ENZOBMLEI3970025
SMER28 (synthétique) ≥98% (par CCM)
SMER28
Small molecule inducer of autophagy important for neurodegenerative disease research.
Chemical inducer of autophagy which acts via an mTOR-independent mechanism. It increased autophagosome synthesis and enhanced the clearance of model autophagy substrates such as A53T alpha-synuclein and mutant huntingtin fragments. It reduced Aβ peptide and AAP-CTF levels in an alzheimers model and attenuated mutant huntingtin-fragment toxicity in Huntington's disease models, suggesting therapeutic potential.
Soluble in DMSO (8 mg/ml) or 100% ethanol (2 mg/ml).