ENZOBMLST3400025EA
657.8
EUR
InStock
ENZOBMLST3400025
ENZOBMLST3400005
Haloenol lactone suicide substrate ≥98% (par CCM)
Haloenol lactone suicide substrate
HELSS is a potent, irreversible, mechanism-based inhibitor of Ca2+-independent PLA2 (70% inhibition at 100 nM). It possesses a 1000-fold selectivity for Ca2+-independent PLA2 vs. Ca2+-dependent PLA2 . It has been used to identify the PLA2 involved in the release of arachidonate induced by vasopressin stimulation of A-10 smooth muscle cells (IC50=1 µM). It has also been shown to inhibit the Mg2+-dependent phophatidate phosphohydrolase from P388D1 macrophages (IC50~8 µM).
White solid.
Soluble in DMSO (25mg/ml).