BMLN1590001
BMLN1590005
ENZOBMLN1590001EA
133.1
EUR
InStock
ENZOBMLN1590001
ENZOBMLN1590005
Gambogic amide ≥98% (par CCM)
Gambogic amide
TrkA ligand
A novel small molecule NGF mimic discovered using a cell-based chemical genetic screen for TrkA agonists. Gambogic amide selectively binds to TrkA, triggers its tyrosine phosphorylation, elicits PI3-kinase/Akt and MAPK activation, provokes neurite outgrowth in PC12 cells and prevents neuronal cell death. EC50 for antiapoptotic activity is 5nM.
Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml).