Synonyms:
3-(3-(tert-Butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid, 3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid Na, L-663,536
BMLEI2660005
BMLEI2660025
ENZOBMLEI2660005EA
110
EUR
InStock
ENZOBMLEI2660005
ENZOBMLEI2660025
MK-886 ≥98% (par HPLC)
MK-886
Inhibitor of PPARα activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase. IC50’s for leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. Induces apoptosis through the mitochondrial pathway.
White solid.
Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml).