Synonyms:
2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride, PJ34 HCl
ALX270289M001
ALX270289M005
ALX270289M025
ENZOALX270289M001EA
83.6
EUR
InStock
ENZOALX270289M001
ENZOALX270289M005
ENZOALX270289M025
PJ-34 hydrochloride (synthétique) ≥98% (par HPLC)
PJ-34 hydrochloride
Potent, water soluble poly(ADP-ribose) polymerase (PARP) inhibitor (EC50=20nM compared to EC50=200µM of the prototypical PARP inhibitor 3-aminobenzamide). Inhibits peroxynitrite-induced cell necrosis (EC50=20nM). Has significant, dose-dependent, anti-inflammatory effects in a variety of local inflammation models and provides cardioprotection by decreasing myocardial infarct size.
White to light brown or yellow powder.
Soluble in DMSO (up to 30 mg/ml) or water (up to 20 mg/ml).