Synonyms:
(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulphonyl]homopiperazine 2HCl, H-1152P 2HCl
ALX270423M001
ALX270423M005
ALX270423M025
ENZOALX270423M001EA
97.9
EUR
InStock
ENZOALX270423M001
ENZOALX270423M005
ENZOALX270423M025
H-1152 dihydrochloride ≥98% (par HPLC)
H-1152 dihydrochloride
A cell permeable, highly specific, potent and ATP-competitive inhibitor of Rho kinase (ROCK) (Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA, 9.27mM for PKC and 10.1mM for MLCK). More potent and selective than Y-27632. Inhibits the phosphorylation of MARCKS in cells stimulated by lysophosphatidic acid. Inhibits EP3-stimulated NO formation. Prevents fragmentation of apoptotic cells. Relieves neuropathic pain.
White to off-white solid.
Soluble in water.