ALX380014C100
ALX380014C250
ALX380014M001
ALX380014M005
ENZOALX380014C100EA
72.6
EUR
InStock
ENZOALX380014C100
ENZOALX380014C250
ENZOALX380014M001
ENZOALX380014M005
Staurosporine ≥98% (par HPLC)
Staurosporine
Apoptosis inducer.
- Protein kinase inhibitor
- Isolated from Streptomyces staurosporeus
- Off-white to green powder
- Soluble in ethyl acetate, DMSO (25 mg/ml); dimethyl formamide (25 mg/ml) and slightly soluble in chloroform and methanol
- Insoluble in water
Potent cell-permeable inhibitor of a variety of protein kinases, e.g. protein kinase C (PKC), CDK1/cyclin B (IC50~5 nM), CDK2/cyclin A (IC50=7 nM), CDK4/cyclin D (IC50=3-10 µM), CDK5/p25 (IC50=4 nM), GSK-3β (IC50=15 nM), Pim-1 kinase (IC50=10 nM).Binds do the ATP binding domain. Did not inhibit PKC-ζ. At 1 µM induced apoptosis in CHO cells. Inhibits topoisomerase II directly by blocking transfer of phosphodiester bonds from DNA to active site tyrosine.