ALX430049M005
ALX430049M025
ALX430049M100
ENZOALX430049M005EA
51.7
EUR
InStock
ENZOALX430049M005
ENZOALX430049M025
ENZOALX430049M100
Zinc protoporphyrin ≥95% (par CCM)
Zinc protoporphyrin
Potent and selective inhibitor of heme oxygenase (Ki=3nM), the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50=0.8µM, 4.0µM, and 5.0µM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier. An useful tool to elucidate the role of CO in signal transduction and as a neurotransmitter.
Dark solid.
Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base; slightly soluble in aqueous base/organic solvent mixtures.