Synonyms:
Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate, rel-(R)-Ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate(relative)
ALX430101M005
ALX430101M025
ENZOALX430101M005EA
84.7
EUR
InStock
ENZOALX430101M005
ENZOALX430101M025
HA14-1 ≥95% (par 1H-RMN)
HA14-1
Bcl-2 ligand
Antagonizes the function of Bcl-2 and induces apoptosis. In HL-60 cells, HA4-1 (50 µM and 4 h incubation) induced apoptosis of more than 90% of the cells. Apoptosis is blocked by ZVAD-FM. IC₅₀= ~9 µM for competition with Flu-BakBH3 binding to Bcl-2.
Soluble in DMSO (25 mg/ml), dimethyl formamide or halogenated solvents; also soluble in 100% ethanol (25 mg, 7 ml hot).