ALX480093M001
ALX480093M005
ENZOALX480093M001EA
271
EUR
InStock
ENZOALX480093M001
ENZOALX480093M005
8-(4-Chlorophenylthio)-2'-O-methyladenosine-3,5-cyclic monophosphate sodium salt ≥98% (par HPLC)
8-(4-Chlorophenylthio)-2'-O-methyladenosine-3,5-cyclic monophosphate sodium salt
Specific, potent and membrane permeant activator of the Epac cAMP receptor.
Activates Epac1 and Epac2, the guanine nucleotide-exchange factors (GEFs) for the small GTPases Rap1 and Rap2. Does not activate protein kinase A (PKA), neither in vitro nor in vivo and is therefore a valuable tool to specifically discriminate between PKA- and Epac-mediated effects. Since a free 2'-ribose hydroxyl group in cyclic AMP is essential for stimulation of PKA, the methylated structure of 8-CPT-2'-O-Me-cAMP is an extremely poor PKA activator.
Its high lipophilicity allows for good membrane permeability in most biosystems and its increased resistance towards phosphodiesterases prevents rapid hydrolysis.
Hygroscopic and soluble in water, aqueous buffers, DMSO, dimethyl formamide or methanol.