M-Clarity™ quality level = MQ300
A1895-25G
A1895-5G
A1895-25GEA
320
EUR
InStock
A1895-25G
A1895-5G
Acide 5,5'-(3-carboxy-4-oxocyclohexa-2,5-dienylidenemethylene)disalicylique ≥85%, en poudre, "Practical" pour titrage, Sigma-Aldrich®
Acide 5,5'-(3-carboxy-4-oxocyclohexa-2,5-dienylidenemethylene)disalicylique
Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca²⁺ -impermeable GluR2 receptors and inhibits calpain, a Ca²⁺ -activated protease that is activated during apoptosis.
- Aurintricarboxylic acid has been used to show its anticryptosporidial activity against Cryptosporidium parvum
- It has been used as a test substance to identify inhibitors against coronavirus N7-MTases (guanine-N7-methyltransferase)
- It has been used as a ribonuclease inhibitor