ICNA02100557.5EA
194
EUR
InStock
ICNA02100557.5
ICNA0210055705
ICNA02100557.1
ICNA0210055701
Streptozocine ≥97% (~75% α-anomer basis), poudre blanc cassé
Streptozocine
Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.
- Extinction Coefficient (E1%): EmM(228 nm): 6.36 (ethanol)
- Biological half-life in cell culture medium was shown to be approximately 19 minutes.
Streptozocin is used to induce Type 1 diabetes for medical research. It has been used for the treatment of malignant insulinoma It is used mainly in the treatment of pancreatic (islet-cell) tumors.
An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.
Soluble in water (50 mg/mL - clear to slightly hazy, light yellow solution) and ethanol.