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Ace+Method+Development+Kits
Numéro de catalogue:
(BOSSBS-11597R-A488)
Fournisseur:
Bioss
Description:
Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q21-q22, respectively.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11596R-A555)
Fournisseur:
Bioss
Description:
Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p15 and 14q21-q22, respectively.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11596R-A680)
Fournisseur:
Bioss
Description:
Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p15 and 14q21-q22, respectively.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12401R-A647)
Fournisseur:
Bioss
Description:
The Notch signaling pathway is an evolutionary conserved system that is involved in intracellular communication. Notch receptors play an important role in development and cell-fate decisions. Notchless is a loss-of-function mutant allele that encodes for protein NLE1 (notchless homolog 1). NLE1 is a 485 amino acid WD40-repeat protein that binds to the cytoplasmic domain of Notch, regulating its signaling activity in Drosophila melanogaster and in mice. Deletion of the NLE1 gene in mice during the early stages of development results in embryonic death, while gene deletion in the late stages of development leads to activation of a caspase-3-dependent apoptotic pathway. In plants, NLE1 is crucial for normal cellular growth and development. Under-expression during shoot proliferation causes pleiotropic defects such as delayed flowering and abnormal organ maturation. It may also play a role in 60S ribosomal subunit biogenesis in yeast. NLE1 contains eight WD40 domains and produces one isoform due to alternative splicing.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11552R-A555)
Fournisseur:
Bioss
Description:
The engrailed-2 gene, EN2, a murine homolog of the Drosophila homeobox gene engrailed (EN), is required for midbrain and cerebellum development and dorsal/ventral patterning of the limbs as well as apical ectodermal ridge formation. In Drosophila, the EN gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Human EN-1 and EN-2 are homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. Different mutations in the mouse homologs, EN-1 and EN-2, produce different developmental defects that frequently are lethal. EN-1 is highly expressed by essentially all dopaminergic neurons in the substantia nigra and ventral tegmentum. EN-1 and EN-2 regulate expression of a-synuclein, a gene that is genetically linked to Parkinson’s disease. During early brain development mouse EN-2 is expressed in a broad band across most of the mid-hindbrain region. EN-2 is also expressed in mouse myoblasts and has been assiciated with cerebellar hypoplasia.
UOM:
1 * 100 µl
Numéro de catalogue:
(1.73634.0001)
Fournisseur:
Merck
Description:
Câble pour mises à jour de méthodes Spectroquant® pour Move 100
UOM:
1 * 1 ST
Numéro de catalogue:
(7140-20)
Fournisseur:
MACRON AVANTOR BRAND
Description:
Potassium sulfate ≥99.0%, granuleux, AR® ACS, Macron Fine Chemicals™
UOM:
1 * 12 kg
Numéro de catalogue:
(BOSSBS-7684R)
Fournisseur:
Bioss
Description:
ALS2CR8 may be a transcription factor. It binds to the calcium-response element CaRE1 and may play a key role in neuronal development and plasticity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11552R-A680)
Fournisseur:
Bioss
Description:
The engrailed-2 gene, EN2, a murine homolog of the Drosophila homeobox gene engrailed (EN), is required for midbrain and cerebellum development and dorsal/ventral patterning of the limbs as well as apical ectodermal ridge formation. In Drosophila, the EN gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Human EN-1 and EN-2 are homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. Different mutations in the mouse homologs, EN-1 and EN-2, produce different developmental defects that frequently are lethal. EN-1 is highly expressed by essentially all dopaminergic neurons in the substantia nigra and ventral tegmentum. EN-1 and EN-2 regulate expression of a-synuclein, a gene that is genetically linked to Parkinson's disease. During early brain development mouse EN-2 is expressed in a broad band across most of the mid-hindbrain region. EN-2 is also expressed in mouse myoblasts and has been associated with cerebellar hypoplasia.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4264R-A555)
Fournisseur:
Bioss
Description:
May regulate transcription during sexual development.
UOM:
1 * 100 µl
Fournisseur:
VWR Chemicals
Description:
Ce produit peut développer une coloration jaune-brun au cours du stockage.
Fournisseur:
VWR Chemicals
Description:
Sodium nitrite ≥99.0%, AnalaR NORMAPUR® ACS, Reag. Ph. Eur.
Fournisseur:
Merck
Description:
Les solvants EMSURE® sont adaptés à un large éventail d'applications classiques de laboratoire et sont fréquemment utilisés pour des applications réglementées et hautement exigeantes.
Fournisseur:
Merck
Description:
tert-Butanol, EMSURE® ACS, Reag. Ph. Eur. pour analyses, Supelco®
Fournisseur:
Merck
Description:
Diphényl-1,5-carbazide ACS, Reag. Ph. Eur. pour analyses, Supelco®
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est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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