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Numéro de catalogue: (BOSSBS-8583R)

Fournisseur:  Bioss
Description:   Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.
UOM:  1 * 100 µl

Fournisseur:  ANTIBODIES.COM
Description:   Recombinant mouse monoclonal [rS100A4/1481] antibody to S100A4 for Flow Cytometry, WB, IF and IHC-P with samples derived from Human and Mouse.
UOM:  1 * 1 EA
New Product
Numéro de catalogue: (ANTIA248803-100)

Fournisseur:  ANTIBODIES.COM
Description:   Mouse monoclonal [SPM256] antibody to Histone H1 for flow cytometry, IF, WB and IHC-P with samples derived from human, mouse and rat.
UOM:  1 * 1 EA
New Product
Numéro de catalogue: (ANTIA250778-100)

Fournisseur:  ANTIBODIES.COM
Description:   Recombinant rabbit monoclonal [CLIP/3127R] antibody to CD74 for Flow Cytometry and IHC-P with samples derived from Human, Baboon and Mouse.
UOM:  1 * 1 EA
New Product
Numéro de catalogue: (ANTIA253683-100)

Fournisseur:  ANTIBODIES.COM
Description:   Mouse monoclonal [OKT3] antibody to CD3 epsilon for Flow Cytometry, IHC-Fr, IF and Functional Studies with samples derived from human.
UOM:  1 * 1 EA
New Product

Fournisseur:  ANTIBODIES.COM
Description:   Rabbit monoclonal [ARC51750] antibody to CD3 epsilon for WB, IHC and flow cytometry with samples derived from human, mouse and rat.
UOM:  1 * 100 µl
New Product
Numéro de catalogue: (ANTIA250504-100)

Fournisseur:  ANTIBODIES.COM
Description:   Mouse monoclonal [RIV9] antibody to CD3 epsilon for Functional Studies, Flow Cytometry and IF with samples derived from Human, Mouse and Rat.
UOM:  1 * 1 EA
New Product
Fournisseur:  ANTIBODIES.COM
Description:   Mouse monoclonal [MEM-233] antibody to CD80 (PerCP) for flow cytometry with samples derived from human.
UOM:  1 * 100 T
New Product
Fournisseur:  ANTIBODIES.COM
Description:   Mouse monoclonal [MEM-31] antibody to CD8 (PerCP) for flow cytometry with samples derived from human.
UOM:  1 * 100 T
New Product
Fournisseur:  ANTIBODIES.COM
Description:   Mouse monoclonal [MEM-06] antibody to CD41 (PerCP) for flow cytometry with samples derived from human.
UOM:  1 * 100 T
New Product
Fournisseur:  ANTIBODIES.COM
Description:   Mouse monoclonal [MEM-CD148/05] antibody to CD148 (APC) for Flow Cytometry with samples derived from Human.
UOM:  1 * 100 T
New Product
Fournisseur:  ANTIBODIES.COM
Description:   Mouse monoclonal [MEM-241] antibody to CD4 (APC-Cyanine 7) for Flow Cytometry with samples derived from human.
UOM:  1 * 100 T
New Product

Fournisseur:  ANTIBODIES.COM
Description:   Mouse monoclonal [MEM-31] antibody to CD8 (APC-Cyanine 7) for Flow Cytometry with samples derived from human.
UOM:  1 * 100 T
New Product

Fournisseur:  ANTIBODIES.COM
Description:   Mouse monoclonal [MEM-12] antibody to HLA DR (APC) for flow cytometry with samples derived from human.
UOM:  1 * 100 T
New Product
Numéro de catalogue: (PRSI26-521)

Fournisseur:  ProSci Inc.
Description:   The exact function of PURG is not known, however, it is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. Two transcript variants encoding different isoforms have been found for this gene.
UOM:  1 * 50 µG
Numéro de catalogue: (ANTIA277866-100)

Fournisseur:  ANTIBODIES.COM
Description:   Mouse monoclonal [BTN399] antibody to Biotin for Flow Cytometry, IF, WB and IHC-P.
UOM:  1 * 1 EA
New Product
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Le stock de cet article est limité mais peut être disponible dans un entrepôt proche de vous. Merci de vous assurer que vous êtes connecté sur le site afin que le stock disponible soit affiché. Si l'call est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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