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PharmaPure®+Precision+Pump+Tubing
Numéro de catalogue:
(BOSSBS-7048R-CY5)
Fournisseur:
Bioss
Description:
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling. Regulates cell adhesion and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7048R-A750)
Fournisseur:
Bioss
Description:
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalisation and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling. Regulates cell adhesion and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity.
UOM:
1 * 100 µl
Numéro de catalogue:
(216-0832)
Fournisseur:
VWR Collection
Description:
Polystyrene.
UOM:
1 * 5 ST
Numéro de catalogue:
(BOSSBS-5504R-A680)
Fournisseur:
Bioss
Description:
Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34C, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5504R-A555)
Fournisseur:
Bioss
Description:
Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.
UOM:
1 * 100 µl
Fournisseur:
Avantor Fluid Handling
Description:
Maintain flexibility at high pressure.
Fournisseur:
VWR Collection
Description:
Portoirs, Test tube, VWR®, Portoir pour tubes à essai en acier inoxydable pour bains de 12 et 18 l, Nb de places: 48, Pour tubes: 1,5 ml
Fournisseur:
PEAK SCIENTIFIC
Description:
The smallest hydrogen generator for GC-FID, Precision hydrogen SL has been developed to offer a streamlined laboratory-grade hydrogen gas solution for GC flame detectors at a purity of 99,9995%. Precision hydrogen SL is safe, simple to use, easy to maintain and takes up minimal bench space.
Fournisseur:
VWR Collection
Description:
En PP.
Fournisseur:
MEMMERT
Description:
Ce stérilisateur est conforme à toutes les normes et réglementations applicables aux produits médicaux et garantit des séquences de programme fiables, indépendamment de la charge et du volume de la cuve. Grâce notamment à la fonction SetpointWAIT, la validation de ce stérilisateur à air chaud est possible à tout moment. La fonction SetpointWAIT garantit que le programme n'est poursuivi que lorsque la température de consigne est atteinte. Le maintien précis du temps de stérilisation et par conséquent l'élimination complète des micro-organismes, même les plus résistants, sont donc garantis à tout moment, indépendamment de la charge de stérilisation et du volume de la cuve. Cette fonction peut également être utilisée avec des capteurs de température Pt100 supplémentaires, librement positionnables. Dans ce cas, la stérilisation ne commence que lorsque la température de consigne est atteinte à tous les points de mesure, c'est-à-dire dans la charge. Pour l'application spéciale de la dépyrogénisation, le stérilisateur à air chaud est absolument idéal. Les modèles SF sont équipés d'un affichage unique.
Fournisseur:
BOCHEM
Description:
These non serrated precision forceps are available in pure stainless steel or with PTFE coating.
Fournisseur:
VWR Collection
Description:
En acier inoxydable. La durée de vie des piles est d'environ 10000 heures.
Numéro de catalogue:
(216-2988)
Fournisseur:
VWR Collection
Description:
Designed for pre- and post-PCR sampling, streamline your PCR workflow with the 32-Place PCR rack. This versatile rack accommodates 0,2 ml tubes both individually and in strips of 8, as well as 32-place assay plates (8×4).
UOM:
1 * 10 ST
Fournisseur:
UVEX
Description:
Adaptée au montage mural, cette station de nettoyage pour verres de lunettes est fournie avec deux paquets de lingettes sans silicone et 500 ml de solution de nettoyage (avec pompe).
Fournisseur:
Avantor Fluid Handling
Description:
No kinks or distortion.
Fournisseur:
AMARELL, ARNO
Description:
Low hazard precision thermometers are used for special applications and suitable for government calibration.
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 est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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