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Anticorps
Numéro de catalogue:
(BOSSBS-13007R)
Fournisseur:
Bioss
Description:
Dyskerin (NAP57) associates with the chaperone protein Nopp140 and forms a small ribonucleoprotein particle with GAR1 (NOLA1), NHP2 (NOLA2) and Nop10 for the isomerization of uridine to pseudouridine (1). GAR1, NHP2 and dyskerin localize to the dense fibrillar component of the nucleolus and in nuclear Cajal bodies (2). The dyskerin gene maps to chromosome Xq28 (3). Missense mutations in the dyskerin gene interfere with normal nuclear localization of dyskerin and cause Dyskeratosis congenita (DKC) (4). DKC is a rare, X-linked bone marrow disorder characterized by cutaneous hyperpigmentation, dystrophy of the nails, atrophy of the testicles and leukoplakia of the oral mucosa. The GAR1 gene maps to chromosome 4q25 (5,6). The NHP2 gene maps to chromosome 5q35.3 and encodes a 155-amino acid protein (2,7).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12004R)
Fournisseur:
Bioss
Description:
Neurotensin (NT) initiates an intracellular response by interacting with the G protein-coupled receptors NTR1 (NTS1 receptor, high affinity NTR) and NTR2 (NTS2 receptor, levocabastine-sensitive neurotensin receptor), and the type I receptor NTR3 (NTS3 receptor, sortilin-1, Gp95). NT has a wide distribution in regions of the brain and in peripheral tissues where NT receptors can contribute to hypotension, hyperglycemia, hypothermia, antinociception and regulation of intestinal motility and secretion. HL-60 cells express NTR1, which can couple to Gq, Gi/o, or Gs. Alternative splicing of rat NTR2 can generate a 5-transmembrane domain variant isoform that is co-expressed with the full-length NTR2 throughout the brain and spinal cord. NTR3 activation in the murine microglial cell line N11 induces MIP-2, MCP-1, IL-1beta and TNF?in an ERK1/2 and Akt kinase-dependent manner.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12996R)
Fournisseur:
Bioss
Description:
Antimicrobial peptides participate in the innate response, which may provide a barrier for protection against infection. The Dermcidin gene encodes an antimicrobial peptide DCD-1, which is constitutively expressed in sweat glands, secreted into the sweat, and transported to the epidermal surface. DCD-1 displays antimicrobial activity in response to a variety of pathogenic microorganisms. Overexpression of Dermcidin in breast cancers promotes cell growth and survival, and is coupled with a focal copy number gain of its locus on human chromosome 12q13.2.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12999R)
Fournisseur:
Bioss
Description:
Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12984R)
Fournisseur:
Bioss
Description:
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD) containing adapter molecules and members of the ICE/CED3 protease family. A novel DD containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx is a death domain containing important intermediate in the Fas mediated apoptosis. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N terminal kinase (JNK) pathway. It is widely expressed in fetal and adult human and mouse tissue, indicating its important function in Fas signaling pathways.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12980R)
Fournisseur:
Bioss
Description:
Protein kinase termed (DAPK2) dependant on calcium/calmodulin (Ca2+/CaM) contains an N-terminal protein kinase domain followed by a conserved CaM-binding domain with significant homologies to those of DAP kinase, a protein kinase involved in apoptosis. Overexpression of DAPK2 significantly induced the morphological changes characteristic of apoptosis. Results indicate that DAPK2 is an additional member of DAP kinase family involved in apoptotic signaling.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13004R)
Fournisseur:
Bioss
Description:
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).
UOM:
1 * 100 µl
Fournisseur:
Biotium
Description:
Recognizes a protein of 27 kDa, identified as the Bcl-X protein. This MAb shows no cross-reaction with Bcl-2 or Bax protein. Bcl-X has two isoforms, Bcl-XL (long), a 241 amino acid protein which suppresses cell death. And Bcl-XS (short), a 178 amino acid protein lacking a 63 amino acid domain which functions as a dominant inhibitor of Bcl-2. This MAb reacts with both Bcl-XS and Bcl-XL proteins.
Numéro de catalogue:
(USBIM9520-11B)
Fournisseur:
US Biological
Description:
Anti-Muscarinic Acetylcholine Receptor M2 Rabbit Polyclonal Antibody
UOM:
1 * 100 µl
Numéro de catalogue:
(USBIM9515-01U)
Fournisseur:
US Biological
Description:
Anti-MSI1 Mouse Monoclonal Antibody [clone: 3F2]
UOM:
1 * 50 µG
Numéro de catalogue:
(USBIF0018-11F)
Fournisseur:
US Biological
Description:
Anti-F10 Rat Monoclonal Antibody [clone: 11C170]
UOM:
1 * 1 EA
Numéro de catalogue:
(USBI037135-BIOTIN)
Fournisseur:
US Biological
Description:
Anti-ITGA5 Rabbit Polyclonal Antibody (Biotin)
UOM:
1 * 200 µl
Numéro de catalogue:
(USBI037131-BIOTIN)
Fournisseur:
US Biological
Description:
Anti-ITFG1 Rabbit Polyclonal Antibody (Biotin)
UOM:
1 * 200 µl
Numéro de catalogue:
(USBI038881-PE)
Fournisseur:
US Biological
Description:
Anti-NEIL2 Rabbit Polyclonal Antibody (PE (Phycoerythrin))
UOM:
1 * 200 µl
Numéro de catalogue:
(USBI140775)
Fournisseur:
US Biological
Description:
Anti-Immunoglobulin G4 Mouse Monoclonal Antibody [clone: 13j52]
UOM:
1 * 200 µG
Numéro de catalogue:
(USBI127281)
Fournisseur:
US Biological
Description:
Anti-GFRA1 Mouse Monoclonal Antibody [clone: 3E4]
UOM:
1 * 1 EA
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