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Protéines et Peptides
Numéro de catalogue:
(PRSI96-124)
Fournisseur:
ProSci Inc.
Description:
CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins, which is also known as Activated leukocyte cell adhesion molecule (ALCAM) in human, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat. CD166 is a cell adhesion molecule that binds to CD6. CD166 involved in neurite extension by neurons via heterophilic and homophilic interactions.
UOM:
1 * 200 µG
Numéro de catalogue:
(PRSI96-122)
Fournisseur:
ProSci Inc.
Description:
Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon γ. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB-signaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-120)
Fournisseur:
ProSci Inc.
Description:
Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon γ. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB-signaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3491P)
Fournisseur:
ProSci Inc.
Description:
Raptor peptide is used for blocking the activity of the Raptor antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6757P)
Fournisseur:
ProSci Inc.
Description:
TSHZ2 peptide is used for blocking the activity of TSHZ2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-188)
Fournisseur:
ProSci Inc.
Description:
Chloride intracellular channel protein 3 (CLIC3) is encoded by the CLIC3 gene. CLIC3 is a single-pass membrane protein which belongs to the chloride channel CLIC family. It contains one GST C-terminal domain and one GST N-terminal domain. Chloride intracellular channel protein 3 high expressed in the placental, lung and heart, low expressed in skeletal muscle, kidney and pancreas. Chloride intracellular channel protein 3 can insert into membranes and forms chloride ion channels, may participate in cellular growth control.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3457P)
Fournisseur:
ProSci Inc.
Description:
Caspase-5 peptide is used for blocking the activity of Caspase-5 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7067P)
Fournisseur:
ProSci Inc.
Description:
CITED2 peptide is used for blocking the activity of CITED2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI1112P)
Fournisseur:
ProSci Inc.
Description:
CCR5 peptide is used for blocking the activity of CCR5 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI1121P)
Fournisseur:
ProSci Inc.
Description:
NTN peptide is used for blocking the activity of neurturin antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI1115P)
Fournisseur:
ProSci Inc.
Description:
RAIDD peptide is used for blocking the activity of RAIDD antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-169)
Fournisseur:
ProSci Inc.
Description:
Ubiquitin-Like Protein ISG15 (ISG15) is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha and -beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signalling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. ISG15 becomes conjugated to a diverse set of proteins after IFN-alpha/beta stimulation or microbial challenge. The functions or biochemical consequences ISG15 conjugation to proteins are not yet known, but it appears that this modification does not target proteins for proteasomal degradation. ISG15 shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. Upon interferon treatment, ISG15 can be detected in both free and conjugated forms and is secreted from monocytes and lymphocytes where it can function as a cytokine. In the cell, ISG15 co-localises with intermediate filaments and ISGylation may modulate the JAK-STAT pathway or certain aspects of neurological disease.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-170)
Fournisseur:
ProSci Inc.
Description:
alpha-Taxilin belongs to the taxilin family. alpha-Taxilin exists in almost all tissues, with higher expression levels observed in the heart, kidney, liver, and pancreas. alpha-Taxilin binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A, and STX4A, but not when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that do not form the SNARE complex. It is shown that alpha-Taxilin plays multiple roles in the generation and maintenance of neurons through modulation of the NAC-mediated translational machinery and/or the syntaxin-mediated vesicle traffic in the soma. In addition, alpha-Taxilin may be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-155)
Fournisseur:
ProSci Inc.
Description:
Ubiquitin-Conjugating Enzyme E2 R2 (UBE2R2) is a modification enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2R2 is involved in cell growth and transformation. It accepts ubiquitin from the E1 complex and catalyses its covalent attachment to other proteins. In vitro, UBE2R2 catalyses monoubiquitination and 'Lys-48'-linked polyubiquitination. It may be involved in degradation of katenin.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-167)
Fournisseur:
ProSci Inc.
Description:
Signal Transducer and Activator of Transcription 5b (STAT5B) is a member of the STAT family of transcription factors. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. STAT5B mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signalling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Signal transduction and activator of transcription 5 (STAT5) is a member of the Jak/STAT signal transduction pathway and is activated by a variety of cytokines (IL22, IL6). STAT5 has two isoforms (A and B) that share 93% amino acid identity and bind the DNA consensus site TTCN3GAA. STAT5 mediates cytokine signalling by acting as a signal transducer in the cytoplasm and, upon phosphorylation, translocates to the nucleus and activates transcription of specific genes. STAT5 is involved in a wide array of biological processes ranging from regulating apoptosis to adult mammary gland proliferation, differentiation and survival.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-156)
Fournisseur:
ProSci Inc.
Description:
Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 can be detected in the placenta, colon, liver, and skin. It forms a heterodimer with UBE2N. The UBE2V2/UBE2N heterodimer catalyses the synthesis of non-canonical poly-ubiquitin chains and which leads to protein degradation by the proteasome. UBE2V2 mediates transcriptional activation of target genes. It plays a role in the control of progress through the cell cycle and differentiation. It also plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
UOM:
1 * 50 µG
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