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Protéines et Peptides
Numéro de catalogue:
(PRSI91-054)
Fournisseur:
ProSci Inc.
Description:
The Galectin family of proteins (with specificity for Nacetyllactosamine containing glycoproteins) consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs). At least 14 mammalian galectins family members that share structural similarities in their carbohydrate recognition domains (CRD) have been identified to date. Unlike the selectin family of proteins, the carbohydrate binding specificity of galectins is calcium-independent. A common function of galectins is to cross-link structures containing N-acetyl-lactosamine located at the cell surface and within the extracellular matrix. They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. They have diverse effects on many cellular functions including adhesion, migration, polarity, chemotaxis, proliferation, apoptosis, and differentiation. Galectins may therefore play a key role in many pathological states, including autoimmune diseases, allergic reactions, inflammation, tumor cell metastasis, atherosclerosis, and diabetic complications. The galectins have been classified into the prototype galectins (1, 2, 5, 7, 10, 11, 13, 14), which contain one CRD and exist either as a monomer or a noncovalent homodimer. The chimera galectins (Galectin3) containing one CRD linked to a nonlectin domain, and the tandem repeat Galectins (4, 6, 8, 9, 12) consisting of two CRDs joined by a linker peptide. Galectins lack a classical signal peptide and can be localized to the cytosolic compartments where they have intracellular functions. However, via one or more as yet unidentified nonclassical secretory pathways, galectins can also be secreted to function extracellularly. Individual members of the galectin family have different tissue distribution profiles and exhibit subtle differences in their carbohydrate-binding specificities. Each family member may preferentially bind to a unique subset of cell surface glycoproteins.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-682)
Fournisseur:
ProSci Inc.
Description:
Phosphatidylinositol 4-Kinase beta (PI4KB) belongs to the PI3/PI4-kinase family and Type III PI4K subfamily. PI4KB contains one PI3K/PI4K domain and one PIK helical domain. It is highly expressed in heart, skeletal muscle, pancreas, testis and ovary,; it is lowly expressed in liver tissue. PI4KB kinase activity can be inhibited by wortmannin, and increased by interacting with NCS1/FREQ. PI4KB phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). In addition, PI4KB may regulate Golgi disintegration/reorganization during mitosis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5849P)
Fournisseur:
ProSci Inc.
Description:
SCRN1 peptide is used for blocking the activity of SCRN1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI40-610)
Fournisseur:
ProSci Inc.
Description:
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein. Recombinant rat TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-245)
Fournisseur:
ProSci Inc.
Description:
Visinin-Like Protein 1 (VILIP) is a a member of the Visinin/Recoverin subfamily of neuronal calcium sensor proteins. VILIP is strongly expressed in the Granule Cells of the Cerebellum where it associates with membranes in a Calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of Adenylyl Cyclase. It has been shown that VILIP regulates the inhibition of rhodopsin phosphorylation in a Calcium-dependent manner in vitro.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7289P)
Fournisseur:
ProSci Inc.
Description:
15 amino acids near the carboxy terminus of human ERRF2.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7269P)
Fournisseur:
ProSci Inc.
Description:
17 amino acid peptide near the center of human PRKCDBP.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7263P)
Fournisseur:
ProSci Inc.
Description:
15 amino acids near the carboxy terminus of human KREMEN2.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7251P)
Fournisseur:
ProSci Inc.
Description:
18 amino acid peptide near the carboxy terminus of human RC3H1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7233P)
Fournisseur:
ProSci Inc.
Description:
16 amino acid peptide near the center of human IL-15RA.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-372)
Fournisseur:
ProSci Inc.
Description:
C1q R1 is also known as CD93, collectin receptor, and AA4 antigen, belongs to the Group XIV C-Type lectin family which play a role not only in cell–cell adhesion processes but also in host defence. All of them contain a C-type lectin domain, a series of epidermal growth factor like domains (EGF), a highly glycosylated mucin-like domain, a unique transmembrane domain and a short cytoplasmic tail. C1q R1 has also been identified as a hematopoietic stem cell marker.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-462)
Fournisseur:
ProSci Inc.
Description:
Discoidin, CUB and LCCL domain-containing protein 2(DCBLD2) is a protein contains 1 CUB domain, 1 F5/8 type C domain, 1 LCCL domain. DCBLD2 is Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells. Model organisms have been used in the study of DCBLD2 function. Male and female animals underwent a standardised phenotypic screen to determine the effects of deletion. Additional screens performed: In-depth immunological phenotyping.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5749P)
Fournisseur:
ProSci Inc.
Description:
SAE1 peptide is used for blocking the activity of SAE1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5751P)
Fournisseur:
ProSci Inc.
Description:
SAE2 peptide is used for blocking the activity of SAE2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-451)
Fournisseur:
ProSci Inc.
Description:
Human recombinant interleukin 29 (from HEK293 cells)
UOM:
1 * 20 µG
Numéro de catalogue:
(PRSI91-889)
Fournisseur:
ProSci Inc.
Description:
Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) is a single-pass type I membrane protein belonging to the LAMP family. LAMP1 is expressed largely in the endosome-lysosome membranes of cells.It shuttles between lysosomes, endosomes, and the plasma membrane. LAMP1 functions to present carbohydrate ligands to selectins and it has also been implicated in tumor cell metastasis. It has been proposed LAMP1 can be used as a therapeutic agent for certain cancers, as well as a marker for lysosomal storage disorders and degranulation on lymphocytes such as CD8+ and NK cells. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells(PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
UOM:
1 * 50 µG
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