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Anticorps
Fournisseur:
Biotium
Description:
PAb122 binds to the C-terminus (aa370-378) of both wild type and mutated p53. When microinjected into nuclei, PAb122 blocked re-entry into the S-phase of the cell cycle. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. p53 Binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. p53 Is the most commonly mutated gene in spontaneously occurring human cancers. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation.
Fournisseur:
Biotium
Description:
Recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Fournisseur:
Biotium
Description:
Recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Numéro de catalogue:
(USBIG2022-98)
Fournisseur:
US Biological
Description:
Anti-GC Rabbit Polyclonal Antibody
UOM:
1 * 200 µl
Numéro de catalogue:
(USBI039116)
Fournisseur:
US Biological
Description:
Anti-NR1I3 Rabbit Polyclonal Antibody
UOM:
1 * 200 µl
Numéro de catalogue:
(USBIN6889-81)
Fournisseur:
US Biological
Description:
Anti-Nuclear Receptor LXR alpha Mouse Monoclonal Antibody [clone: 8C247]
UOM:
1 * 50 µG
Numéro de catalogue:
(USBI039114-BIOTIN)
Fournisseur:
US Biological
Description:
Anti-NR1H3 Rabbit Polyclonal Antibody (Biotin)
UOM:
1 * 200 µl
Numéro de catalogue:
(USBI034022-APC)
Fournisseur:
US Biological
Description:
Anti-CLUL1 Rabbit Polyclonal Antibody (APC (Allophycocyanin))
UOM:
1 * 200 µl
Numéro de catalogue:
(USBI041077-AP)
Fournisseur:
US Biological
Description:
Anti-RM33 Rabbit Polyclonal Antibody (AP (Alkaline Phosphatase))
UOM:
1 * 200 µl
Numéro de catalogue:
(ABGEAP18517A)
Fournisseur:
Abgent
Description:
Anti-BAX Rabbit Polyclonal Antibody
UOM:
1 * 400 µl
Numéro de catalogue:
(ABGEAP18112B)
Fournisseur:
Abgent
Description:
Anti-MYH9 Rabbit Polyclonal Antibody
UOM:
1 * 400 µl
Numéro de catalogue:
(ABGEAP18113A)
Fournisseur:
Abgent
Description:
Anti-ITGB2 Rabbit Polyclonal Antibody
UOM:
1 * 400 µl
Numéro de catalogue:
(ABGEAP18105C)
Fournisseur:
Abgent
Description:
Anti-LRR1 Rabbit Polyclonal Antibody
UOM:
1 * 400 µl
Numéro de catalogue:
(USBI042442-HRP)
Fournisseur:
US Biological
Description:
Anti-STX6 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
UOM:
1 * 200 µl
Numéro de catalogue:
(USBI149933)
Fournisseur:
US Biological
Description:
Anti-KCNJ1 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(USBI149935)
Fournisseur:
US Biological
Description:
Anti-JAM2 Goat Polyclonal Antibody
UOM:
1 * 1 EA
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