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Bioss
Numéro de catalogue:
(BOSSBS-11785R-A555)
Fournisseur:
Bioss
Description:
Maspardin is a 308 amino acid cytoplasmic protein that is widely expressed. Belonging to the AB hydrolase superfamily, Maspardin colocalizes with CD4 on endosomal/trans-Golgi network. It is thought that Maspardin may act as a negative regulatory factor in CD4-dependent T-cell activation. Defects in the gene encoding Maspardin are the result of hereditary spastic paraplegia autosomal recessive type 21 (also designated Mast syndrome), an autosomal recessive neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. The gene encoding Maspardin is encoded by human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3437R-CY7)
Fournisseur:
Bioss
Description:
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3437R-CY5.5)
Fournisseur:
Bioss
Description:
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7641R-A555)
Fournisseur:
Bioss
Description:
ACSM3
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1851R-A750)
Fournisseur:
Bioss
Description:
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13017R-FITC)
Fournisseur:
Bioss
Description:
Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1852R-CY3)
Fournisseur:
Bioss
Description:
DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4045R-A750)
Fournisseur:
Bioss
Description:
KHK encodes the gene ketohexokinase that catalyses conversion of fructose to fructose 1 phosphate. The splice variant presented encodes the highly active form found in liver, renal cortex, and small intestine, while the alternate variant encodes the lower activity form found in most other tissues.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6704R-HRP)
Fournisseur:
Bioss
Description:
The septins are a family of cytoskeletal GTPases that play an essential role in cytokinesis in mammalian cells. Septin 2 (Nedd5) is a mammalian septin known to associate with actin based structures such as the contractile ring and stress fibers. It is involved in cytokinesis and may assemble into a multicomponent structure.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6704R-CY5)
Fournisseur:
Bioss
Description:
The septins are a family of cytoskeletal GTPases that play an essential role in cytokinesis in mammalian cells. Septin 2 (Nedd5) is a mammalian septin known to associate with actin based structures such as the contractile ring and stress fibers. It is involved in cytokinesis and may assemble into a multicomponent structure.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2883R-A555)
Fournisseur:
Bioss
Description:
This protein belongs to a G protein coupled heptahelical receptor subfamily named Endothelial Cell Differentiation Genes (EDG)that act as receptors for biologically active lysophospholipids. This group consists of two receptor subgroups specific for S1P and LPA respectively. EDG6 is the receptor for lysophospholipid sphingosine 1 phosphate (S1P). S1P elicits diverse physiological effect on most types of cells and tissues. EDG6 may be involved in cell migration processes that are specific for lymphocytes.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6706R-CY3)
Fournisseur:
Bioss
Description:
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6706R-CY7)
Fournisseur:
Bioss
Description:
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6706R-A555)
Fournisseur:
Bioss
Description:
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-10280R-HRP)
Fournisseur:
Bioss
Description:
Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary; lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1037R-A555)
Fournisseur:
Bioss
Description:
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
UOM:
1 * 100 µl
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