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Bioss
Numéro de catalogue:
(BOSSBS-7856R-CY3)
Fournisseur:
Bioss
Description:
Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known.Tissue specificity:Predominantly expressed in skin.Involvement in diseaseDefects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE). NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7817R-A647)
Fournisseur:
Bioss
Description:
Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May bind and transfer 2 labile 4Fe-4S clusters to target apoproteins.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3936R-HRP)
Fournisseur:
Bioss
Description:
Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7698R-CY5.5)
Fournisseur:
Bioss
Description:
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11320R-A647)
Fournisseur:
Bioss
Description:
Putative transcription factor involved in pancreas development and function.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7697R-FITC)
Fournisseur:
Bioss
Description:
Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3997R-A647)
Fournisseur:
Bioss
Description:
Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7758R-CY5)
Fournisseur:
Bioss
Description:
Tissue specificity: Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7817R-HRP)
Fournisseur:
Bioss
Description:
Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May bind and transfer 2 labile 4Fe-4S clusters to target apoproteins.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7761R-CY3)
Fournisseur:
Bioss
Description:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11365R-FITC)
Fournisseur:
Bioss
Description:
In all vertebrates, SV2 proteins are abundant, hydrophobic, membrane glycoproteins that are expressed as two major isoforms, SV2A and SV2B, and one minor isoform, SV2C. SV2 proteins are differentially expressed in the brain and are present on all synaptic vesicles, independent of transmitter type. SV2A is abundantly expressed in the subcortex, specifically in the synaptic vesicles of all presynaptic nerve terminals, and also in most neuroendocrine secretory granules. SV2B displays a more restricted pattern of expression in that it is only present on a small subset of synapses in the hippocampus and cortex. SV2A and SV2B are funtionally redundant and are required for maintaining normal brain function in vertebrates. SV2A and SV2B mediate synaptic transmission by regulating cytoplasmic Ca2+ levels in the nerve terminal during repetitive stimulation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11366R-A488)
Fournisseur:
Bioss
Description:
In all vertebrates, SV2 proteins are abundant, hydrophobic, membrane glycoproteins that are expressed as two major isoforms, SV2A and SV2B, and one minor isoform, SV2C. SV2 proteins are differentially expressed in the brain and are present on all synaptic vesicles, independent of transmitter type. SV2A is abundantly expressed in the subcortex, specifically in the synaptic vesicles of all presynaptic nerve terminals, and also in most neuroendocrine secretory granules. SV2B displays a more restricted pattern of expression in that it is only present on a small subset of synapses in the hippocampus and cortex. SV2A and SV2B are funtionally redundant and are required for maintaining normal brain function in vertebrates. SV2A and SV2B mediate synaptic transmission by regulating cytoplasmic Ca2+ levels in the nerve terminal during repetitive stimulation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7818R-A350)
Fournisseur:
Bioss
Description:
Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May bind and transfer a labile 4Fe-4S cluster to target apoproteins.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11367R-CY7)
Fournisseur:
Bioss
Description:
Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7818R-CY5)
Fournisseur:
Bioss
Description:
Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May bind and transfer a labile 4Fe-4S cluster to target apoproteins.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6805R-FITC)
Fournisseur:
Bioss
Description:
CLUAP1 (Clusterin associated protein 1) is a 413 amino acid nuclear protein that exists as two alternatively spliced isoforms that interact with Clusterin. CLUAP1 is suggested to play a role in apoptosis and cell proliferation, and is expressed in testis, thrachea and thyroid, with low levels found in adrenal gland and spinal cord. The gene encoding CLUAP1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
UOM:
1 * 100 µl
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