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Bioss
Numéro de catalogue:
(BOSSBS-6239R-A750)
Fournisseur:
Bioss
Description:
SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterised by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalisation. Once internalised, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6239R-FITC)
Fournisseur:
Bioss
Description:
SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1226R-A647)
Fournisseur:
Bioss
Description:
The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319 amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213 amino acid extracellular region, a single transmembrane domain, and a 62 amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5362R-FITC)
Fournisseur:
Bioss
Description:
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12313R-A750)
Fournisseur:
Bioss
Description:
Probably involved in bone and dentin mineralization and renal phosphate reabsorption.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8168R-CY5.5)
Fournisseur:
Bioss
Description:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8168R-HRP)
Fournisseur:
Bioss
Description:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4062R-CY3)
Fournisseur:
Bioss
Description:
Glycerol kinase catalyzes the formation of glycerol 3 phosphate from ATP and glycerol. Dihydroxyacetone and L glyceraldehyde can also act as acceptors; UTP and, in the case of the yeast enzyme, ITP and GTP can act as donors. It provides a way for glycerol derived from fats or glycerides to enter the glycolytic pathway.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4062R-A555)
Fournisseur:
Bioss
Description:
Glycerol kinase catalyzes the formation of glycerol 3 phosphate from ATP and glycerol. Dihydroxyacetone and L glyceraldehyde can also act as acceptors; UTP and, in the case of the yeast enzyme, ITP and GTP can act as donors. It provides a way for glycerol derived from fats or glycerides to enter the glycolytic pathway.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12183R-HRP)
Fournisseur:
Bioss
Description:
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha-subunits (KV alpha), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KV beta subunits that modify the gating properties of the coexpressed KV alpha subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8168R-FITC)
Fournisseur:
Bioss
Description:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5795R-A750)
Fournisseur:
Bioss
Description:
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-0226R-FITC)
Fournisseur:
Bioss
Description:
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13198R-HRP)
Fournisseur:
Bioss
Description:
The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4210R-A680)
Fournisseur:
Bioss
Description:
hydrolyses acyl-CoA thioesters (in vitro). Has a preference for substrates with medium chain length (C1-C14). Inactive towards substrates with C18 or C2 aliphatic chains. Its physiological substrate is not known.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11730R-A350)
Fournisseur:
Bioss
Description:
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha-subunits (KV alpha), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KV beta subunits that modify the gating properties of the coexpressed KV alpha subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.
UOM:
1 * 100 µl
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